IELTS Reading Practice Test 6 · Passage 1
The long defeat of scurvy
How a deadly disease of the sea was finally understood
For more than three centuries, the greatest danger facing sailors on long voyages was not storms, enemy ships or shipwreck, but a disease. Scurvy began with tiredness and aching limbs; then the gums swelled and bled, teeth became loose, and wounds that had healed years before opened up again. Without treatment, the sufferer eventually died. During the great voyages of exploration, ships often lost a large part of their crews to the disease, and by some estimates it killed as many as two million sailors between the sixteenth and the nineteenth centuries. The disease was also known on land, in besieged cities and during famines, but it was at sea, where crews might go for months without fresh food, that it did the most damage.
Many remedies were tried, and most of them were useless. Some doctors blamed damp air below deck, others the sailors' laziness or their salty diet. In 1747, however, a Scottish naval surgeon named James Lind decided to test some of the most popular treatments in a systematic way. On board HMS Salisbury, he selected twelve sailors who were suffering from scurvy and whose symptoms were as similar as possible. He divided them into six pairs, kept them in the same part of the ship and gave them the same basic diet, but each pair also received a different remedy: cider, a weak solution of sulphuric acid, vinegar, sea water, a spicy paste, or two oranges and a lemon every day.
The results were dramatic. The two men who were given citrus fruit recovered so quickly that within a week one of them was fit for duty and the other was well enough to nurse the remaining patients. Those who drank cider showed a slight improvement; the rest showed none. Lind's experiment is now often described as one of the first controlled clinical trials in the history of medicine, because he compared several treatments under the same conditions at the same time. By modern standards, of course, twelve patients is far too small a number for firm conclusions.
Yet the story did not end there. Lind published his findings in 1753 in a long book, A Treatise of the Scurvy, but he presented the citrus result as one observation among many, and he himself continued to believe that the disease had several causes and to recommend a number of other treatments alongside fruit. Moreover, because fresh fruit spoiled quickly at sea, he recommended preserving the juice by boiling it down into a thick syrup. Unknown to him, this process destroyed most of the substance that made the fruit effective, and ships that relied on the syrup gained little protection.
It was another forty years before the navy acted. In 1795, largely as a result of a campaign by the physician Gilbert Blane, the Admiralty began to issue a daily ration of fresh lemon juice to every sailor in the Royal Navy. The effect was remarkable: within a few years, scurvy had almost disappeared from British warships, and the navy's ability to keep ships at sea for long periods became a significant advantage in the wars that followed.
In the second half of the nineteenth century, however, the disease returned. The navy had begun to replace lemons from the Mediterranean with limes, which could be obtained from Britain's own colonies in the Caribbean. Nobody realised that limes contain far less of the protective substance than lemons, or that the juice lost much of its strength when it was stored for long periods. When a British expedition set out to explore the Arctic in 1875, its supplies of lime juice failed to prevent an outbreak of scurvy, and many doctors began to doubt whether citrus fruit worked at all.
The answer finally came from an unexpected direction. In 1907, two Norwegian doctors, Axel Holst and Theodor Frølich, were studying a different disease in animals. When they fed guinea pigs on a diet of grain, the animals developed scurvy, something that had never been seen in laboratory animals before. Guinea pigs, it turned out, are one of the very few animals that, like humans, cannot make the protective substance in their own bodies. For the first time, researchers had a way of testing which foods prevented the disease.
In 1932, the Hungarian scientist Albert Szent-Györgyi and, independently, the American Charles Glen King identified the substance itself, which became known as vitamin C. Its chemical name, ascorbic acid, comes from the Latin word for scurvy. Szent-Györgyi was awarded the Nobel Prize in 1937; in the same year, the British chemist Walter Haworth, who had worked out its structure and how to make it in the laboratory, received the Nobel Prize in chemistry. Almost two centuries after Lind's experiment, the cause of scurvy was finally understood.